Oncology/Hematology

News, opinions and meeting coverage in oncology/hematology.

Can Tumor Mutational Burden Guide Treatment in Metastatic Breast Cancer?

Hormone receptor-positive patients with high TMB may fare well with immunotherapy

A photo of the FDA headquarters building as seen behind FDA logos at a bus stop on the agency’s campus.

FDA Proposes New Testing Rules to Ensure Cosmetics Are Asbestos-Free

Proposal comes after years of lawsuits alleging links between talc-based baby powder and cancer

Onco Break over a computer rendering of a cancer cell.

Metastatic Cancer 'Thrivers'; Celebrity Cancer Diagnoses; 'Would He Have Lived?'

News, features, and commentary about cancer-related issues

Mezigdomide Combinations Show Promise in Multiple Myeloma

High rates of durable response in difficult-to-treat disease, with good tolerability

A photo of a man receiving chemotherapy.

Patient Endured 9 Years of Chemotherapy for Cancer He Never Had

"I thought he was helping me"

Frontline Mosunetuzumab Shows High Response Rates in Follicular Lymphoma

Promising single-agent efficacy with manageable safety may reshape initial treatment

A computer rendering of a transparent body with a bladder tumor highlighted.

Biomarker-Selected Treatment Shows Promise for Bladder Preservation in MIBC

Almost half of patients in active surveillance avoided cystectomy during 40 months of follow-up

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Congress Ditched Fix to Medicare Doc Pay Cut in Skinny Budget Bill

One warns of "dangerous game" in continuing Medicare pay cuts

Adding Daratumumab to VRd Boosts MRD Negativity in Transplant-Ineligible Myeloma

Study paves the way for quadruple therapy in patients not eligible for a stem cell transplant

New BCMA-Directed Therapies Show Promise in Multiple Myeloma

Reduced toxicity and improved convenience position new treatments for broader use

Specialist Referrals Are Critical for Functional High-Risk Multiple Myeloma

Rapid evaluation and novel therapies may improve outcomes for these patients

Chemo-Free Regimen for Ph+ ALL Yields High Rate of Deep MRD Negativity

Ponatinib-blinatumomab led to durable remissions without transplant in most, but 13% relapsed

A photo of a man holding a cardboard container of four to-go cups of coffee.

Coffee, Tea Tied to Lower Risk of Head and Neck Cancer

Meta-analysis shows inverse dose-response relationship for both beverages

Electronic Sepsis Alerts; Reducing Plaques in Coronary Arteries

Also in TTHealthWatch: electronic nudges for flu shots

Onco Break over a computer rendering of a cancer cell.

No Seed Oil-Colon Cancer Link; Avoiding Prostate Biopsy; Top Cancer Advances

News, features, and commentary about cancer-related issues

A computer rendering of breast cancer.

Sticking With CDK4/6 Inhibitors for Breast Cancer Wins in Post-Progression Setting

Lack of biomarkers handicaps decision making in era of expanding treatment options

A computer rendering of a transparent head with brain metastases highlighted.

Asymptomatic Brain Metastases in EGFR-Mutant NSCLC

Newest EGFR TKIs have changed the game for treating asymptomatic brain metastases

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Randy Moss' Rare GI Cancer: Here's What to Know

Hall of Fame football player recently revealed his cholangiocarcinoma diagnosis

Quads, Frailty, and the Future: Evolving Frontline Strategies in Multiple Myeloma

Experts at ASH debate quadruplet therapy, dexamethasone modulation, and novel approaches

Health of Myeloma Patient's Marriage Tied to Recovery After Transplant

Study links strong relationships to better physical and emotional outcomes in myeloma care

Optimizing Sequencing of BCMA-Directed Therapies in Myeloma

Longer gaps between anti-BCMA agents associated with improved response rates, study finds

Mosunetuzumab in Follicular Lymphoma: Durable Responses and Manageable Safety

Experts talk about long-term data and the importance of infection prophylaxis

FDA APPROVED remestemcel-L (Ryoncil) over a photo of a bag of stem cells in a purple rubber-gloved hand.

FDA Approves Mesenchymal Stromal Cell Therapy for Refractory Acute GVHD in Kids

Response rate of 70% at day 28 with remestemcel-L

FDA APPROVED ensartinib (Ensacove) over a computer rendering of lung cancer.

New First-Line Option for Advanced ALK-Positive Lung Cancer

In randomized study, ensartinib doubled PFS versus first-generation ALK inhibitor

A photo of a young man discussing his chemotherapy treatment with his male doctor.

What Comes After Cancer?

Alarming mental health challenges among young cancer survivors, especially males, demand action

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Skipping Chest-Wall Irradiation After Mastectomy in Intermediate-Risk Breast Cancer

No improvement in survival or impact on recurrence, but pending studies leave door ajar

Experts Debate AQUILA Trial Findings in Smoldering Multiple Myeloma

Phase III trial sparks discussion on defining and managing high-risk smoldering myeloma

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

Randy Moss Has Cancer; Nancy Pelosi's Surgery; Possible Bird Flu Case Hospitalized

Health news and commentary gathered by MedPage Today staff

SABCS over a photo of the Henry B. Gonzalez Convention Center in San Antonio, TX.

A Setback for TNBC Monitoring With Circulating Tumor DNA in ZEST Trial

Study was stopped early due to enrollment issues, but lessons can still be learned

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Homing in on Anthracyclines' High-Risk Niche in Early Breast Cancer

Significant improvement in 5-year distant relapse-free interval with higher risk score

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Better Quality of Life With RT vs Endocrine Therapy in Older Breast Cancer Patients

Radiotherapy also resulted in fewer treatment-related adverse events

Onco Break over a computer rendering of a cancer cell.

Hair Growth After Cancer; 'Global' Early-Onset CRC; Retifanlimab Boosts OS in NSCLC

News, features, and commentary about cancer-related issues

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

No Apparent Harm From Omitting Lymph Node Dissection in Selected Breast Cancers

Nearly identical 5-year outcomes with no surgery, sentinel lymph node biopsy

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Palbociclib Regimen Yields 'Incredible' PFS Gain in Metastatic Breast Cancer

Study results are "historic," expert says

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Risk-Reducing Surgery May Benefit BRCA Carriers With Early-Onset Breast Cancer

Lower rates of mortality and cancer recurrence with mastectomy, salpingo-oophorectomy

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Skip Surgery for DCIS in Favor of Active Monitoring?

No invasive cancer increase at 2 years, but editorialists say data don't back active monitoring

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Lung Cancer Drug Osimertinib Tied to Cardiac Events, Even in Low-Risk Patients

Signal largely driven by newly emerging arrhythmias

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Industry Clinic • Ad Insights

Subcutaneous Cancer Immunotherapies Provide New Options for Physicians and Patients

ASH over a photo of San Diego Convention Center

Pulled Myeloma Drug Improves Survival in Trial

DREAMM-7 findings help pave the way for Blenrep's return

SABCS over a photo of Henry B. Gonzalez Convention Center in San Antonio, TX.

Oral SERD Impresses in Advanced Breast Cancer With ESR1 Mutations

However, imlunestrant failed to improve PFS among entire trial population

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